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SAM-e
Also known as s-adenosyl methionine, methylguanidoacetic acid
SAM-e
S-Adenosyl Methionine · Methylguanidoacetic Acid
Overview
Summary sheet: SAM-e SAM-e
Sources & licencesPsychonautWiki·PubChem chemical identifiers
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C[S+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)OTags1 tag
Dose
?
Safety
- Addiction potential
- not habit-forming with a low potential for abuse
EffectsPsychonautWikiEffectIndex
Tactile
2Muscle twitching
Muscle twitching can be described as the sensation of small and localised tremblings of muscle groups. These vibrations are often powerful enough to be visibly seen through the skin. It is most commonly induced under the influence of moderate dosages of stimulating psychedelic compounds such as LSD, 2C-E, DOC, and AMT.
Open full explainer on EffectIndex↗Tactile enhancement
Tactile enhancement is an overall increase in both the intensity of a person's sense of touch and their awareness of the physical sensations across their body. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Physical & bodily
9Appetite suppression
Appetite suppression can be described as the experience of a distinct decrease in a person's sense of hunger and appetite in a manner which can result in both a lesser desire to eat food and a decreased enjoyment of its taste. It is most commonly induced under the influence of moderate dosages of stimulant compounds, such as amphetamine, methylphenidate, nicotine, MDMA, and cocaine.
Open full explainer on EffectIndex↗Bodily control enhancement
Bodily control enhancement can be described as feeling as if there has been a distinct increase in a person's ability to control their physical body with precision, balance, coordination, and dexterity. It is most commonly induced under the influence of moderate dosages of stimulating psychedelics, such as LSD, 2C-B, and DOC.
Open full explainer on EffectIndex↗Dehydration
Dehydration can be described as an uncomfortably dry mouth and feelings of general thirstiness that results due to a lack of water intake. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as, stimulants, psychedelics, opioids, dissociatives, deliriants, cannabinoids, alcohol, and antipsychotics.
Open full explainer on EffectIndex↗Diarrhea
Diarrhea or diarrhoea is the condition of having at least three loose or liquid bowel movements each day. It is most commonly induced under the influence of heavy dosages of certain psychedelic compounds, such as ayahuasca, mescaline, and psilocybin mushrooms.
Open full explainer on EffectIndex↗Headache
A headache can be described as a pain anywhere in the region of the head or neck. It can be a symptom of a number of different conditions. They are most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants, certain psychedelics, and certain dissociatives.
Open full explainer on EffectIndex↗Pain relief
Pain relief can be described as an effect which suppresses negative sensations such as aches and pains. It is most commonly induced under the influence of moderate dosages of a very wide variety of compounds, such as opioids, GABAergics, GABApentinoids, cannabinoids, dissociatives, muscle relaxants, and NSAID's.
Open full explainer on EffectIndex↗Stamina enhancement
Stamina enhancement can be described as an increased ability to engage in physically and mentally taxing activities without the development of fatigue. It most commonly occurs under the influence of stimulants such as amphetamine and specific psychedelics such as LSD.
Open full explainer on EffectIndex↗Stimulation
Stimulation can be described as an increase in a person's physical energy levels. It is most commonly induced under the influence of stimulant compounds, such as amphetamine, MDMA, and cocaine.
Open full explainer on EffectIndex↗Stomach cramp
A stomach cramp can be described as an intense feeling of sudden pain or discomfort which occurs within the stomach. They are most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, and deliriants.
Open full explainer on EffectIndex↗Cognitive
13Analysis enhancement
Analysis enhancement is a perceived improvement of a person's overall ability to logically process information or creatively analyze concepts, ideas, and scenarios. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, nicotine, and caffeine.
Open full explainer on EffectIndex↗Anxiety suppression
Anxiety suppression (also known as anxiolysis or minimal sedation) is medically recognized as a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of both psychological and physiological tension. It is most commonly induced under the influence of moderate dosages of anxiolytic compounds which primarily include GABAergic depressants, such as benzodiazepines, alcohol, GHB, and gabapentinoids.
Open full explainer on EffectIndex↗Cognitive euphoria
Cognitive euphoria (semantically the opposite of cognitive dysphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of well-being, elation, happiness, excitement, and joy. It is most commonly induced under the influence of moderate dosages of opioids, entactogens, stimulants, and GABAergic depressants. However, it can also occur to a lesser extent under the influence of hallucinogenic compounds such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Focus enhancement
Focus enhancement is the experience of an increased ability to selectively concentrate on an aspect of the environment while ignoring other things. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, modafinil, and caffeine
Open full explainer on EffectIndex↗Irritability
Irritability is medically recognized as the pervasive and sustained emotional state of being easily annoyed and provoked to anger. It is most commonly induced during the after effects of heavy dosages of stimulant compounds, such as cocaine, methamphetamine, and methylphenidate.
Open full explainer on EffectIndex↗Mania
Mania can be described as a state of abnormally elevated energy levels and general arousal. It is most commonly induced under the influence of heavy dosages of stimulant or dissociative compounds, such as methamphetamine, PCP, 2-Oxo-PCE, and cocaine.
Open full explainer on EffectIndex↗Memory enhancement
Memory enhancement is an improvement in a person's ability to recall or retain memories. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as methylphenidate, caffeine, Noopept, nicotine, and modafinil.
Open full explainer on EffectIndex↗Mindfulness
Mindfulness is the self-regulation of attention so that focus is directed towards immediate experience alongside of an orientation characterized by acceptance and a lack of judgement. It can occur under the influence of substances but is also practiced during meditation.
Open full explainer on EffectIndex↗Motivation enhancement
Motivation enhancement is an increased desire to perform tasks and accomplish goals in a productive manner. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, nicotine, and modafinil.
Open full explainer on EffectIndex↗Rejuvenation
Rejuvenation can be described as feelings of mild to extreme cognitive refreshment which are felt during the afterglow of certain compounds. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics and dissociatives.
Open full explainer on EffectIndex↗Thought connectivity
Thought connectivity is an alteration of a person's thought stream which is characterized by a distinct increase in wandering thoughts which connect into each other through a fluid association of ideas. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Thought organization
Thought organization (also known as fluid intelligence) is as a state of mind in which one's ability to analyze and categorize conceptual information using a systematic and logical thought process is considerably increased. It is most commonly induced under the influence of mild dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, and Noopept
Open full explainer on EffectIndex↗Wakefulness
Wakefulness is an increased ability to stay conscious without feeling sleepy combined with a decreased need to sleep. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as stimulants, nootropics, and psychedelics.
Open full explainer on EffectIndex↗No effects match that search.
Timing
Only onset and total duration are available for this route, so an intensity curve would be misleading.
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