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Promethazine
Also known as phenergan, lergigan
Promethazine
Phenergan · Lergigan
Overview
A first generation antihistamine, which possesses anticholinergic, strong sedative and antipsychotic properties. The drug was commonly used as a treatment for psychosis, and is now more typically used as a component of codeine cough syrups as an anti-nausea agent.
Sources & licencesPsychonautWiki·TripSit·PubChem chemical identifiers
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CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)CTags3 tags
Dose
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The drug has deliriant effects at higher dosages.
EffectsPsychonautWikiEffectIndex
Visual
11Autonomous entity
An autonomous entity is the experience of perceived contact with beings that appear to be sentient in their behaviour. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds.
Open full explainer on EffectIndex↗Depth perception distortions
Depth perception distortions are alterations in how a person perceives the distance of various objects within their visual field. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗External hallucination
An external hallucination is the perception of a visual hallucination that displays itself seamlessly into the external environment as if it were physically present. They are most commonly induced under the influence of heavy dosages of deliriant compounds.
Open full explainer on EffectIndex↗Internal hallucination
An internal hallucination is the perception of a visual hallucination that exclusively occurs within an imagined environment that can typically only be viewed with closed eyes, similar to those found within dreams. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Object activation
Object activation is the experience of looking at an object and perceiving it to move, become alive, or become fully animated and autonomous of its own accord. It is most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Open full explainer on EffectIndex↗Peripheral information misinterpretation
Peripheral information misinterpretation is a fleeting experience of an object or detail within one's peripheral vision being interpreted and displayed incorrectly. It is most commonly induced under the influence of moderate dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Open full explainer on EffectIndex↗Perspective hallucination
A perspective hallucination is an alteration of the perspective through which a given internal or external hallucination is seen through. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Settings, sceneries, and landscapes
Settings, sceneries, and landscapes are the perceived environments in which the plot of an internal or external hallucination occurs. This effect is capable of manifesting in a seemingly infinite variety of potential places and settings. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Shadow people
Shadow people are the experience of perceiving patches of shadow in one's peripheral or direct line of sight to appear and behave as living, autonomous beings. They are most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Open full explainer on EffectIndex↗Transformations
Transformations are the experience of a perceived visual metamorphosis that specific parts of one's external environment undergo as they shapeshift into other objects. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Unspeakable horrors
Unspeakable horrors describe the experience of prolonged exposure to indescribable scenarios and hallucinatory content of a scary and disturbing nature, which are often directly influenced by a person's fears. They are most commonly induced under the influence of heavy dosages of psychedelic compounds, such as LSD, psilocybin, and 2C-P.
Open full explainer on EffectIndex↗Transpersonal & hallucinatory
1Scenarios and plots
Scenarios and plots are the situations, stories, and events that occur within both external and internal hallucinations. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Cognitive
7Anxiety
Anxiety is medically recognized as the experience of negative feelings of apprehension, worry, and general unease. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as cannabinoids, psychedelics, dissociatives, and deliriants
Open full explainer on EffectIndex↗Anxiety suppression
Anxiety suppression (also known as anxiolysis or minimal sedation) is medically recognized as a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of both psychological and physiological tension. It is most commonly induced under the influence of moderate dosages of anxiolytic compounds which primarily include GABAergic depressants, such as benzodiazepines, alcohol, GHB, and gabapentinoids.
Open full explainer on EffectIndex↗Confusion
Confusion is an impairment of abstract thinking demonstrated by an inability to think with one’s customary clarity and coherence. It is most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, synthetic cannabinoids, and deliriants.
Open full explainer on EffectIndex↗Delirium
Delirium (also known as acute confusion) is medically recognized as a physiological disturbance of awareness that is accompanied by a change in baseline cognition which cannot be better explained by a preexisting or evolving neurocognitive disorder. The disturbance in awareness is manifested by a reduced ability to direct, focus, sustain, and shift attention and the accompanying cognitive change in at least one other area may include memory and learning (particularly recent memory), disorientation (particularly to time and place), alteration in language, or perceptual distortions or a perceptual-motor disturbance. It is most commonly induced under the influence of heavy dosages of deliriant compounds, such as DPH, datura, and benzydamine.
Open full explainer on EffectIndex↗Delusion
A delusion is a false idea or belief that is held with strong conviction and subjective certainty and is inconsistent with an individual’s educational, cultural and social background. Delusions are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.
Open full explainer on EffectIndex↗Emotion suppression
Emotion suppression (also known as flat affect, apathy, or emotional blunting) is medically recognized as a flattening or decrease in the intensity of one's current emotional state below normal levels. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.
Open full explainer on EffectIndex↗Sleepiness
Sleepiness (also known as drowsiness) is medically recognized as a state of near-sleep, or a strong desire for sleep without feeling a decrease in one's physical energy levels. This state is independent of a circadian rhythm; so, unlike sedation, this effect does not necessarily decrease physical energy levels but instead decreases wakefulness. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as cannabinoids, GABAergic depressants, opioids, antipsychotics, some antihistamines, and certain psychedelics.
Open full explainer on EffectIndex↗Emotional & social
2Euphoria
PsychonautWiki lists Euphoria as a reported subjective effect for Promethazine. A concise EffectIndex summary is not available for this entry.
View on PsychonautWiki↗Physical euphoria
Physical euphoria can be described as feelings of pleasure and comfort within and across one's body. This euphoria typically feels somewhat comparable to the endorphin rushes felt during states of excitement or love, the coziness of a comfortable bed, and the rush of an orgasm. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as opioids, stimulants, psychedelics, and GABAergics.
Open full explainer on EffectIndex↗Physical & bodily
8Abnormal heartbeat
An abnormal heartbeat is any of a group of conditions in which the electrical activity of the heart is irregular. During this state, the heartbeat may be too fast (over 100 beats per minute) or too slow (less than 60 beats per minute) and may be regular or irregular. An abnormal heartbeat is most commonly induced under the influence of moderate dosages of stimulant and depressant compounds, such as cocaine, methamphetamine, and GABAergics.
Open full explainer on EffectIndex↗Difficulty urinating
Difficulty urinating (also known as urinary retention) can be described as the experience of a decreased ability to pass urine. It is most commonly induced under the influence of heavy dosages of stimulant and opioid compounds, such as heroin, fentanyl, kratom, amphetamine, MDMA, and 4-FA.
Open full explainer on EffectIndex↗Dry mouth
Dry mouth can be described as having a dry-feeling mouth often accompanied by a difficulty swallowing. It is usually a direct result of dehydration but can be felt to occur regardless of the actual dryness of a person's mouth. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as stimulants, psychedelics, opioids, antispychotics, deliriants, SSRI's, and cannabinoids.
Open full explainer on EffectIndex↗Increased blood pressure
Increased blood pressure can be described as a condition in which the pressure in the systemic arteries is elevated to abnormal levels. It is most commonly induced under the influence of heavy dosages of deliriants and vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.
Open full explainer on EffectIndex↗Increased heart rate
Increased heart rate or tachycardia is described as a heart rate that is faster than the normal heart rate at rest. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants, certain psychedelics, and certain dissociatives.
Open full explainer on EffectIndex↗Muscle relaxation
Muscle relaxation can be described as the experience of muscles losing their rigidity or tenseness while becoming relaxed and comfortable. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as various benzodiazepines, GABAergics, and opioids.
Open full explainer on EffectIndex↗Nausea suppression
Nausea suppression can be described as a reduction in vomiting, stomach cramps, and general feelings of nausea. It is most commonly induced under the influence of 5-HT3 receptor antagonists, cannabinoids, benzodiazepines, antihistamines, and others.
Open full explainer on EffectIndex↗Sedation
Sedation can be described as a decrease in a person's physical energy levels which are interpreted as discouraging when it comes to wakefulness, movement, performing tasks, talkativeness, and general exercise. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as opioids, GABAergics, and antipsychotics.
Open full explainer on EffectIndex↗No effects match that search.
Timing
Only onset and total duration are available for this route, so an intensity curve would be misleading.
After effects12 hours
Testing
Reagent test reference
The colour bars follow the written reaction sequence from the source. Rows without a bar are explicit results recorded by the source, not missing data. Reagents cannot establish identity, purity, or potency.
Reported appearance: Purple red.
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