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Memantine
Also known as memaxa, ebixa, namenda, namenda xr, namzaric (with donepezil, both extended-release)
Memantine
Memaxa · Ebixa · Namenda · Namenda XR
Overview
An NMDA-antagonist that may produce a prolonged dissociative "hole" experience lasting up to 16+ hours. The drug is used clinically to slow the progression of moderate-to-severe Alzheimer's disease, among other uses=.
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CC12CC3CC(C1)(CC(C3)(C2)N)CTags2 tags
Dose
?
Safety
- Addiction potential
- unknown
- Cross-tolerance with
- dissociatives
EffectsPsychonautWikiEffectIndex
Visual
22After images
After images (also known as palinopsia) are visual perceptions that continue to appear in one's vision after exposure to the original image has ceased. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Autonomous entity
An autonomous entity is the experience of perceived contact with beings that appear to be sentient in their behaviour. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds.
Open full explainer on EffectIndex↗Brightness alteration
Brightness alteration is a distortion or change in the intensity of perceived brightness comprising a person's vision. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Colour enhancement
Colour enhancement is a perceived intensification of the brightness and vividness of colours in the external environment. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Depth perception distortions
Depth perception distortions are alterations in how a person perceives the distance of various objects within their visual field. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Double vision
Double vision is the experience of seeing duplicated vision, similar to when one crosses their eyes. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as alcohol, quetiapine, ketamine, and DXM.
Open full explainer on EffectIndex↗Drifting
Drifting is the experience of the texture, shape, and general structure of objects and scenery appearing progressively warped, melted, and morphed across themselves. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Environmental cubism
Environmental cubism is a visual segmentation of the external environment into squares and cubes of varying amounts and sizes. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Environmental orbism
PsychonautWiki lists Environmental orbism as a reported subjective effect for Memantine. A concise EffectIndex summary is not available for this entry.
View on PsychonautWiki↗External hallucination
An external hallucination is the perception of a visual hallucination that displays itself seamlessly into the external environment as if it were physically present. They are most commonly induced under the influence of heavy dosages of deliriant compounds.
Open full explainer on EffectIndex↗Frame rate suppression
Frame rate suppression is the perceived reduction in speed at which visual information is processed. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, MXE, PCP, and DXM.
Open full explainer on EffectIndex↗Geometry
Geometry is the experience of a person's field of vision becoming partially or completely encompassed by fast-moving, colourful, and extremely complex geometric patterns, form constants, shapes, fractals, and colours.
Open full explainer on EffectIndex↗Internal hallucination
An internal hallucination is the perception of a visual hallucination that exclusively occurs within an imagined environment that can typically only be viewed with closed eyes, similar to those found within dreams. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Perspective hallucination
A perspective hallucination is an alteration of the perspective through which a given internal or external hallucination is seen through. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Scenery slicing
Scenery slicing is the experience of a person's visual field appearing to split into separate, cleanly cut sections. These individual slices then proceed to drift slowly away from their original position before disappearing and resetting to normal. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Settings, sceneries, and landscapes
Settings, sceneries, and landscapes are the perceived environments in which the plot of an internal or external hallucination occurs. This effect is capable of manifesting in a seemingly infinite variety of potential places and settings. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Symmetrical texture repetition
Symmetrical texture repetition is the perception of textures becoming mirrored repeatedly over their own surface in an intricate and symmetrical fashion that is consistent across itself. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Visual acuity enhancement
Visual acuity enhancement is a heightening of the clearness and clarity of vision. It is most commonly induced under the influence of mild dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Visual acuity suppression
Acuity suppression is the degradation of the sharpness and clarity of one's vision, resulting in vision becoming partially to completely blurred and indistinct. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as alcohol, quetiapine, ketamine, and DXM.
Open full explainer on EffectIndex↗Visual agnosia
Visual agnosia is a partial to complete inability to mentally process visual information, regardless of its clarity. It is most commonly induced under the influence of heavy dosages of dissociative or antipsychotic compounds, such as ketamine, quetiapine, PCP, and DXM.
Open full explainer on EffectIndex↗Visual disconnection
Visual disconnection is the experience of becoming distanced and/or detached from one's sense of vision. It is a near-universal effect under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Visual haze
Visual haze distorts the surrounding environment to make it appear as if the air is shrouded in an imaginary cloud of smoke, fog, or haze. It is most commonly induced under the influence of mild dosages of hallucinogenic compounds, such as psychedelics, deliriants, and cannabinoids.
Open full explainer on EffectIndex↗Emotional & social
1Physical euphoria
Physical euphoria can be described as feelings of pleasure and comfort within and across one's body. This euphoria typically feels somewhat comparable to the endorphin rushes felt during states of excitement or love, the coziness of a comfortable bed, and the rush of an orgasm. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as opioids, stimulants, psychedelics, and GABAergics.
Open full explainer on EffectIndex↗Physical & bodily
22Appetite suppression
Appetite suppression can be described as the experience of a distinct decrease in a person's sense of hunger and appetite in a manner which can result in both a lesser desire to eat food and a decreased enjoyment of its taste. It is most commonly induced under the influence of moderate dosages of stimulant compounds, such as amphetamine, methylphenidate, nicotine, MDMA, and cocaine.
Open full explainer on EffectIndex↗Bodily control enhancement
Bodily control enhancement can be described as feeling as if there has been a distinct increase in a person's ability to control their physical body with precision, balance, coordination, and dexterity. It is most commonly induced under the influence of moderate dosages of stimulating psychedelics, such as LSD, 2C-B, and DOC.
Open full explainer on EffectIndex↗Changes in felt gravity
Changes in felt gravity can be described as feeling that the pull of gravity has shifted in its direction. For example, during this state one may feel as if they are floating forwards, backwards, upwards, downwards, or in an unspecifiable direction.
Open full explainer on EffectIndex↗Constipation
Constipation can be described as bowel movements that are infrequent or hard to pass. It usually results in painful defecation and small, compact faeces. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, tramadol, fentanyl, and kratom.
Open full explainer on EffectIndex↗Cough suppression
Cough suppression can be described as a decreased desire and need to cough. It is most commonly induced under the influence of moderate dosages of antitussive compounds such as, codeine, pholcodine, dextromethorphan, noscapine, and butamirate.
Open full explainer on EffectIndex↗Decreased libido
Decreased libido can be described as a distinct decrease in feelings of sexual desire, the anticipation of sexual activity, and the likelihood that a person will view the context of a given situation as sexual in nature. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as, opioids, antipsychotics and SSRI's, and dissociatives.
Open full explainer on EffectIndex↗Difficulty urinating
Difficulty urinating (also known as urinary retention) can be described as the experience of a decreased ability to pass urine. It is most commonly induced under the influence of heavy dosages of stimulant and opioid compounds, such as heroin, fentanyl, kratom, amphetamine, MDMA, and 4-FA.
Open full explainer on EffectIndex↗Dizziness
Dizziness can be described as the perception of a spinning or swaying motion which typically causes a difficulty in standing or walking. It is most commonly induced under the influence of heavy dosages of GABAergic depressant compounds, such as benzodiazepines, alcohol, and GHB.
Open full explainer on EffectIndex↗Headache
A headache can be described as a pain anywhere in the region of the head or neck. It can be a symptom of a number of different conditions. They are most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants, certain psychedelics, and certain dissociatives.
Open full explainer on EffectIndex↗Increased heart rate
Increased heart rate or tachycardia is described as a heart rate that is faster than the normal heart rate at rest. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants, certain psychedelics, and certain dissociatives.
Open full explainer on EffectIndex↗Increased libido
Increased libido can be described as a distinct increase in feelings of sexual desire, the anticipation of sexual activity, and the likelihood that a person will view the context of a given situation as sexual in nature. It is most commonly induced under the influence of moderate dosages of stimulant compounds, particularly dopaminergic stimulants such as methamphetamine and cocaine.
Open full explainer on EffectIndex↗Motor control loss
Motor control loss can be described as feeling as if there has been a distinct decrease in a person's ability to control their physical body with precision, balance, coordination, and dexterity. Motor control loss is often accompanied by other coinciding effects such as sedation and disinhibition. It is most commonly induced under the influence of moderate dosages of GABAergic depressant compounds, such as, alcohol, benzodiazepines, GHB, and phenibut.
Open full explainer on EffectIndex↗Nausea
Nausea can be described as a sensation of unease and discomfort in the upper stomach combined with an involuntary urge to vomit. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, deliriants, dissociatives, and stimulants.
Open full explainer on EffectIndex↗Nausea suppression
Nausea suppression can be described as a reduction in vomiting, stomach cramps, and general feelings of nausea. It is most commonly induced under the influence of 5-HT3 receptor antagonists, cannabinoids, benzodiazepines, antihistamines, and others.
Open full explainer on EffectIndex↗Optical sliding
Optical sliding can be described as a physical effect which inhibits the coordination and control of a person's eyes by suppressing their ability to keep them still. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Orgasm suppression
Orgasm suppression (formally known as anorgasmia) can be described as a difficulty or complete inability to achieve orgasm despite adequate sexual stimulation. This effect commonly occurs on opioids and dissociatives which have been reported to decrease one's ability to feel sexual pleasure, which may be attributed to their tactile suppressing effects or through some other biological mechanism. It is also a well-known side effect of selective serotonin reuptake inhibitors (SSRIs).
Open full explainer on EffectIndex↗Pain relief
Pain relief can be described as an effect which suppresses negative sensations such as aches and pains. It is most commonly induced under the influence of moderate dosages of a very wide variety of compounds, such as opioids, GABAergics, GABApentinoids, cannabinoids, dissociatives, muscle relaxants, and NSAID's.
Open full explainer on EffectIndex↗Perception of bodily lightness
Perception of bodily lightness can be described as feeling as if one's body has significantly decreased in its weight. This can result in feelings of increased energy and a general sense of bounciness due to the body seeming weightless and therefore effortless to move. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Physical autonomy
Physical autonomy can be described as the experience of a person's own body performing simple or complex actions entirely of its own accord. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Physical disconnection
Physical disconnection is the experience of feeling distant and detached from one's sense of touch and their feelings of ownership and control over their own physical body. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as, ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Stamina enhancement
Stamina enhancement can be described as an increased ability to engage in physically and mentally taxing activities without the development of fatigue. It most commonly occurs under the influence of stimulants such as amphetamine and specific psychedelics such as LSD.
Open full explainer on EffectIndex↗Stimulation
Stimulation can be described as an increase in a person's physical energy levels. It is most commonly induced under the influence of stimulant compounds, such as amphetamine, MDMA, and cocaine.
Open full explainer on EffectIndex↗Auditory
4Auditory distortion
An auditory distortion is the experience of perceived alterations in how audible noises present and structure themselves. They are most commonly induced under the influence of hallucinogenic compounds.
Open full explainer on EffectIndex↗Auditory enhancement
An auditory enhancement is the experience of an increase or improvement of the acuteness and clarity of sound. They are most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Auditory hallucination
An auditory hallucination is the experience of hearing spontaneous and imaginary noises. They are most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.
Open full explainer on EffectIndex↗Auditory suppression
Auditory suppression is the experience of sound becoming perceived as more distant, quiet, and muffled than they actually are. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Tactile
2Spontaneous tactile sensations
Spontaneous tactile sensations are the experience of sensations across the body occurring without any obvious or immediate physical trigger. This results in feelings of seemingly random yet distinct tingling sensations that occur across the skin and within the body. Depending on the psychoactive substance consumed, these vary greatly in their styles of sensation.
Open full explainer on EffectIndex↗Tactile suppression
Tactile suppression is a decrease in one's ability to feel their sense of touch, which may result in a general numbness across the body. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Smell & taste
1Gustatory suppression
Gustatory suppression is the experience of tastes becoming significantly vaguer, weaker, and less noticeable than they would be during everyday sobriety. At higher levels, this can result in food becoming completely tasteless and significantly less appealing. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Cognitive
24Amnesia
Amnesia is a global impairment in the ability to acquire new memories regardless of sensory modality, and a loss of some memories, especially recent ones, from the period before amnesia began. It is most commonly induced under the influence of heavy dosages of GABAergic depressants, such as alcohol, benzodiazepines, GHB, and zolpidem.
Open full explainer on EffectIndex↗Analysis suppression
Analysis suppression is a distinct decrease in a person's overall ability to process information and logically or creatively analyze concepts, ideas, and scenarios. It is most commonly induced under the influence of heavy dosages of antipsychotic compounds, and is associated with long term use of such drugs like quetiapine, haloperidol, and risperidone.
Open full explainer on EffectIndex↗Anxiety suppression
Anxiety suppression (also known as anxiolysis or minimal sedation) is medically recognized as a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of both psychological and physiological tension. It is most commonly induced under the influence of moderate dosages of anxiolytic compounds which primarily include GABAergic depressants, such as benzodiazepines, alcohol, GHB, and gabapentinoids.
Open full explainer on EffectIndex↗Cognitive disconnection
Cognitive disconnection is the experience of feeling distant and detached from one's sense of identity, thought stream, and general cognitive processes. It is a near-universal effect under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Cognitive euphoria
Cognitive euphoria (semantically the opposite of cognitive dysphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of well-being, elation, happiness, excitement, and joy. It is most commonly induced under the influence of moderate dosages of opioids, entactogens, stimulants, and GABAergic depressants. However, it can also occur to a lesser extent under the influence of hallucinogenic compounds such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Conceptual thinking
Conceptual thinking is an alteration to the nature and content of one's internal thought stream. This alteration predisposes a user to think thoughts that are no longer primarily comprised of words and linear sentence structures. Instead, thoughts become equally comprised of what is perceived to be extremely detailed renditions of the innately understandable and internally stored concepts that words exist to label. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics and dissociatives.
Open full explainer on EffectIndex↗Creativity enhancement
Creativity enhancement is a perceived increase in one's capability to imagine new ideas, create art, or think about existing concepts in a novel manner. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Deja vu
Déjà Vu or Deja Vu can be described as the sudden sensation that a current event or situation has already been experienced at some point in the past when, in actuality, it hasn't. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Depersonalization
Depersonalization is medically recognized as the experience of feeling detached from one's mental processes, body, or actions as if they are an outside observer. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Derealization
Derealization or derealisation (sometimes abbreviated as DR) is the experience of feeling detached from, and as if one is an outside observer of, one's surroundings (e.g., individuals or objects are experienced as unreal, dreamlike, foggy, lifeless, or visually distorted). It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Disinhibition
Disinhibition is medically recognized as an orientation towards immediate gratification, leading to impulsive behavior driven by current thoughts, feelings, and external stimuli, without regard for past learning or consideration of future consequences. It is most commonly induced under the influence of moderate dosages of GABAergic depressants, such as alcohol, benzodiazepines, phenibut, and GHB.
Open full explainer on EffectIndex↗Dream suppression
Dream suppression is a decrease in the vividness, intensity, frequency, and recollection of a person's dreams. It is most commonly induced under the influence of moderate dosages of cannabinoids and most types of antidepressants.
Open full explainer on EffectIndex↗Existential self-realization
Existential self-realization can be described as a sudden realization, revelation, or reaffirmation of a person's existence within this universe. Existential self-realization is most commonly induced under the influence of moderate dosages of psychedelic and dissociative compounds such as ketamine, LSD, 4-AcO-DMT, and DCK.
Open full explainer on EffectIndex↗Feelings of impending doom
Feelings of impending doom can be described as sudden sensations of overwhelming fear and urgency based upon the unfounded belief that a negative event is about to occur in the immediate future. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Immersion enhancement
Immersion enhancement is an effect that results in a pronounced increase in one's tendency to become fully captivated and engrossed by external stimuli, such as film, TV shows, video games, and various other forms of media. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Increased music appreciation
Increased music appreciation is a general sense of an increased enjoyment of music. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids
Open full explainer on EffectIndex↗Introspection
Introspection can be described as the experience of a state of mind in which a person feels as if they are being encouraged or forced to reflect upon and examine aspects of their life, thoughts, and feelings. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics and dissociatives.
Open full explainer on EffectIndex↗Mania
Mania can be described as a state of abnormally elevated energy levels and general arousal. It is most commonly induced under the influence of heavy dosages of stimulant or dissociative compounds, such as methamphetamine, PCP, 2-Oxo-PCE, and cocaine.
Open full explainer on EffectIndex↗Memory suppression
Memory suppression is an inhibition of a person's ability to maintain a functional short and long-term memory. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Mindfulness
Mindfulness is the self-regulation of attention so that focus is directed towards immediate experience alongside of an orientation characterized by acceptance and a lack of judgement. It can occur under the influence of substances but is also practiced during meditation.
Open full explainer on EffectIndex↗Motivation enhancement
Motivation enhancement is an increased desire to perform tasks and accomplish goals in a productive manner. It is most commonly induced under the influence of moderate dosages of stimulant and nootropic compounds, such as amphetamine, methylphenidate, nicotine, and modafinil.
Open full explainer on EffectIndex↗Personal meaning enhancement
Personal meaning enhancement (also known as aberrant salience) is the experience of a considerably increased sense of personal significance becoming attributed to innocuous situations, and coincidences. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, cannabinoids, and deliriants.
Open full explainer on EffectIndex↗Thought deceleration
Thought deceleration is the process of thought being slowed down significantly in comparison to that of normal sobriety. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, antipsychotics, and opioids.
Open full explainer on EffectIndex↗Time distortion
Time distortion is an effect that makes the passage of time feel wildly altered and difficult to keep track of. is most commonly induced under the influence of strong dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Transpersonal & hallucinatory
2Machinescapes
Machinescapes are a complex visual and tactile experience where one perceives hallucinatory mechanical landscapes that are vast in both size and intricacy. They are most commonly induced under the influence of heavy dosages of salvia divinorum. However, they can also occur less commonly under the influence of psychedelic compounds, such as LSD, psilocybin, and 2C-P.
Open full explainer on EffectIndex↗Scenarios and plots
Scenarios and plots are the situations, stories, and events that occur within both external and internal hallucinations. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Other
1Perspective distortion
PsychonautWiki lists Perspective distortion as a reported subjective effect for Memantine. A concise EffectIndex summary is not available for this entry.
View on PsychonautWiki↗No effects match that search.
Timing
Only onset and total duration are available for this route, so an intensity curve would be misleading.
After effects8-24 hours
Testing
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Reported appearance: Short reddish.
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