Cognitive fatigue (also called exhaustion, tiredness, lethargy, languidness, languor, lassitude, and listlessness) is medically recognized as a state usually associated with a weakening or depletion of one's mental resources. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.

Dream potentiation is an effect that increases the subjective intensity, vividness, and frequency of sleeping dream states. It is most commonly induced under the influence of moderate dosages of oneirogenic compounds, a class of hallucinogen that is used to specifically potentiate dreams when taken before sleep.

Emotion suppression (also known as flat affect, apathy, or emotional blunting) is medically recognized as a flattening or decrease in the intensity of one's current emotional state below normal levels. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone.

Focus suppression is medically recognized as a decreased ability to selectively concentrate on an aspect of the environment while ignoring other things. It is most commonly induced under the influence of moderate or heavy dosages of antipsychotics, benzodiazepines, cannabinoids, and hallucinogens.

Sleepiness (also known as drowsiness) is medically recognized as a state of near-sleep, or a strong desire for sleep without feeling a decrease in one's physical energy levels. This state is independent of a circadian rhythm; so, unlike sedation, this effect does not necessarily decrease physical energy levels but instead decreases wakefulness. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as cannabinoids, GABAergic depressants, opioids, antipsychotics, some antihistamines, and certain psychedelics.

Thought deceleration is the process of thought being slowed down significantly in comparison to that of normal sobriety. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, antipsychotics, and opioids.

Respiratory depression can be described as a reduced urge to breathe that can be fatal depending on its intensity. It is most commonly induced under the influence of heavy dosages of depressant compounds, particularly opioids, such as heroin and fentanyl, or GABAergics, such as alcohol and GHB. However, it is worth noting that otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant.

Constipation can be described as bowel movements that are infrequent or hard to pass. It usually results in painful defecation and small, compact faeces. It is most commonly induced under the influence of heavy dosages of opioid compounds, such as heroin, tramadol, fentanyl, and kratom.

Dehydration can be described as an uncomfortably dry mouth and feelings of general thirstiness that results due to a lack of water intake. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as, stimulants, psychedelics, opioids, dissociatives, deliriants, cannabinoids, alcohol, and antipsychotics.

Difficulty urinating (also known as urinary retention) can be described as the experience of a decreased ability to pass urine. It is most commonly induced under the influence of heavy dosages of stimulant and opioid compounds, such as heroin, fentanyl, kratom, amphetamine, MDMA, and 4-FA.

Excessive yawning can be described as the experience of repeated, intensified, overly frequent, and spontaneous yawning despite a complete absence of genuine sedation or sleepiness. It is most commonly induced under the influence of moderate dosages of tryptamine psychedelic compounds, such as psilocybin, 4-AcO-DMT, 4-HO-MET, and ayahuasca.

Muscle tension can be described as extended partial contractions or over shortening of muscles which can cause persistent low-level aches and pains. It is most commonly induced under the influence of heavy dosages of stimulating psychedelic compounds, such as LSD, 2C-E, DOC, and AMT.

Nausea suppression can be described as a reduction in vomiting, stomach cramps, and general feelings of nausea. It is most commonly induced under the influence of 5-HT3 receptor antagonists, cannabinoids, benzodiazepines, antihistamines, and others.

Physical fatigue can be described as a general feeling of bodily exhaustion. It is most commonly induced under the influence of moderate dosages of antipsychotic compounds, such as quetiapine, haloperidol, and risperidone. However, it can also occur during the withdrawal symptoms of many depressants, and during the offset of many stimulants.

Sedation can be described as a decrease in a person's physical energy levels which are interpreted as discouraging when it comes to wakefulness, movement, performing tasks, talkativeness, and general exercise. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as opioids, GABAergics, and antipsychotics.