PsychonautWiki marks this substance entry as unapproved. Its information may be incomplete or awaiting review.
Also known as hydroxyeticyclidine
3-HO-PCE
Hydroxyeticyclidine
Overview
A rare and very potent PCP analogue, eight times more potent than PCP as a NMDA receptor antagonist. It is also a μ-opioid receptor agonist. Similar in structure to methoxetamine.
Sources & licencesPsychonautWiki·TripSit·PubChem chemical identifiers
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The SMILES and basic chemical identifiers are resolved from the linked PubChem record. Fracton renders the molecule locally as inline SVG.
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CCNC1(CCCCC1)C2=CC(=CC=C2)ODose
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Safety
- Addiction potential
- moderately addictive with a moderate potential for adverse side effects such as psychosis
- Full tolerance
- with prolonged and repeated use
- Half tolerance
- 4 - 7 days
- Zero tolerance
- 1 - 2 weeks
- Cross-tolerance with
- dissociative
EffectsPsychonautWikiEffectIndex
Visual
8Frame rate suppression
Frame rate suppression is the perceived reduction in speed at which visual information is processed. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, MXE, PCP, and DXM.
Open full explainer on EffectIndex↗Internal hallucination
An internal hallucination is the perception of a visual hallucination that exclusively occurs within an imagined environment that can typically only be viewed with closed eyes, similar to those found within dreams. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Perspective hallucination
A perspective hallucination is an alteration of the perspective through which a given internal or external hallucination is seen through. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Scenery slicing
Scenery slicing is the experience of a person's visual field appearing to split into separate, cleanly cut sections. These individual slices then proceed to drift slowly away from their original position before disappearing and resetting to normal. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Settings, sceneries, and landscapes
Settings, sceneries, and landscapes are the perceived environments in which the plot of an internal or external hallucination occurs. This effect is capable of manifesting in a seemingly infinite variety of potential places and settings. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Visual acuity suppression
Acuity suppression is the degradation of the sharpness and clarity of one's vision, resulting in vision becoming partially to completely blurred and indistinct. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as alcohol, quetiapine, ketamine, and DXM.
Open full explainer on EffectIndex↗Visual agnosia
Visual agnosia is a partial to complete inability to mentally process visual information, regardless of its clarity. It is most commonly induced under the influence of heavy dosages of dissociative or antipsychotic compounds, such as ketamine, quetiapine, PCP, and DXM.
Open full explainer on EffectIndex↗Visual disconnection
Visual disconnection is the experience of becoming distanced and/or detached from one's sense of vision. It is a near-universal effect under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Cognitive
18Amnesia
Amnesia is a global impairment in the ability to acquire new memories regardless of sensory modality, and a loss of some memories, especially recent ones, from the period before amnesia began. It is most commonly induced under the influence of heavy dosages of GABAergic depressants, such as alcohol, benzodiazepines, GHB, and zolpidem.
Open full explainer on EffectIndex↗Anxiety suppression
Anxiety suppression (also known as anxiolysis or minimal sedation) is medically recognized as a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of both psychological and physiological tension. It is most commonly induced under the influence of moderate dosages of anxiolytic compounds which primarily include GABAergic depressants, such as benzodiazepines, alcohol, GHB, and gabapentinoids.
Open full explainer on EffectIndex↗Cognitive disconnection
Cognitive disconnection is the experience of feeling distant and detached from one's sense of identity, thought stream, and general cognitive processes. It is a near-universal effect under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Cognitive euphoria
Cognitive euphoria (semantically the opposite of cognitive dysphoria) is medically recognized as a cognitive and emotional state in which a person experiences intense feelings of well-being, elation, happiness, excitement, and joy. It is most commonly induced under the influence of moderate dosages of opioids, entactogens, stimulants, and GABAergic depressants. However, it can also occur to a lesser extent under the influence of hallucinogenic compounds such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Compulsive redosing
Compulsive redosing is the experience of a powerful and difficult to resist urge to continuously redose a psychoactive substance in an effort to increase or maintain the subjective effects which it induces. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as opioids, stimulants, GABAergics, and entactogens.
Open full explainer on EffectIndex↗Conceptual thinking
Conceptual thinking is an alteration to the nature and content of one's internal thought stream. This alteration predisposes a user to think thoughts that are no longer primarily comprised of words and linear sentence structures. Instead, thoughts become equally comprised of what is perceived to be extremely detailed renditions of the innately understandable and internally stored concepts that words exist to label. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics and dissociatives.
Open full explainer on EffectIndex↗Delusion
A delusion is a false idea or belief that is held with strong conviction and subjective certainty and is inconsistent with an individual’s educational, cultural and social background. Delusions are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.
Open full explainer on EffectIndex↗Depersonalization
Depersonalization is medically recognized as the experience of feeling detached from one's mental processes, body, or actions as if they are an outside observer. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Derealization
Derealization or derealisation (sometimes abbreviated as DR) is the experience of feeling detached from, and as if one is an outside observer of, one's surroundings (e.g., individuals or objects are experienced as unreal, dreamlike, foggy, lifeless, or visually distorted). It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Disinhibition
Disinhibition is medically recognized as an orientation towards immediate gratification, leading to impulsive behavior driven by current thoughts, feelings, and external stimuli, without regard for past learning or consideration of future consequences. It is most commonly induced under the influence of moderate dosages of GABAergic depressants, such as alcohol, benzodiazepines, phenibut, and GHB.
Open full explainer on EffectIndex↗Immersion enhancement
Immersion enhancement is an effect that results in a pronounced increase in one's tendency to become fully captivated and engrossed by external stimuli, such as film, TV shows, video games, and various other forms of media. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Increased music appreciation
Increased music appreciation is a general sense of an increased enjoyment of music. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids
Open full explainer on EffectIndex↗Mania
Mania can be described as a state of abnormally elevated energy levels and general arousal. It is most commonly induced under the influence of heavy dosages of stimulant or dissociative compounds, such as methamphetamine, PCP, 2-Oxo-PCE, and cocaine.
Open full explainer on EffectIndex↗Memory suppression
Memory suppression is an inhibition of a person's ability to maintain a functional short and long-term memory. It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Psychosis
Psychosis is as an abnormal condition of the mind and a general psychiatric term for a mental state in which one experiences a "loss of contact with reality." It is most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as deliriants, psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Thought deceleration
Thought deceleration is the process of thought being slowed down significantly in comparison to that of normal sobriety. It is most commonly induced under the influence of heavy dosages of depressant compounds, such as GABAergics, antipsychotics, and opioids.
Open full explainer on EffectIndex↗Thought disorganization
Thought disorganization is a state in which one's ability to analyze and categorize conceptual information using a systematic and logical thought process is considerably decreased. It is most commonly induced under the influence of heavy dosages of hallucinogenic and depressant compounds, such as dissociatives, psychedelics, cannabinoids, and GABAergics.
Open full explainer on EffectIndex↗Time distortion
Time distortion is an effect that makes the passage of time feel wildly altered and difficult to keep track of. is most commonly induced under the influence of strong dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and cannabinoids.
Open full explainer on EffectIndex↗Transpersonal & hallucinatory
1Scenarios and plots
Scenarios and plots are the situations, stories, and events that occur within both external and internal hallucinations. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as psychedelics, dissociatives, and deliriants.
Open full explainer on EffectIndex↗Auditory
3Auditory distortion
An auditory distortion is the experience of perceived alterations in how audible noises present and structure themselves. They are most commonly induced under the influence of hallucinogenic compounds.
Open full explainer on EffectIndex↗Auditory hallucination
An auditory hallucination is the experience of hearing spontaneous and imaginary noises. They are most commonly induced under the influence of moderate dosages of hallucinogenic compounds, such as psychedelics, deliriants, and dissociatives.
Open full explainer on EffectIndex↗Auditory suppression
Auditory suppression is the experience of sound becoming perceived as more distant, quiet, and muffled than they actually are. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Tactile
2Tactile enhancement
Tactile enhancement is an overall increase in both the intensity of a person's sense of touch and their awareness of the physical sensations across their body. It is most commonly induced under the influence of moderate dosages of psychedelic compounds, such as LSD, psilocybin, and mescaline.
Open full explainer on EffectIndex↗Tactile suppression
Tactile suppression is a decrease in one's ability to feel their sense of touch, which may result in a general numbness across the body. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Smell & taste
1Olfactory hallucination
An olfactory hallucination (also known as phantosmia) is the detection or perception of a convincing imaginary smell that is not actually present in the person's environment. They are most commonly induced under the influence of heavy dosages of hallucinogenic compounds, such as deliriants and psychedelics.
Open full explainer on EffectIndex↗Emotional & social
1Respiratory depression
Respiratory depression can be described as a reduced urge to breathe that can be fatal depending on its intensity. It is most commonly induced under the influence of heavy dosages of depressant compounds, particularly opioids, such as heroin and fentanyl, or GABAergics, such as alcohol and GHB. However, it is worth noting that otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant.
Open full explainer on EffectIndex↗Physical & bodily
16Appetite suppression
Appetite suppression can be described as the experience of a distinct decrease in a person's sense of hunger and appetite in a manner which can result in both a lesser desire to eat food and a decreased enjoyment of its taste. It is most commonly induced under the influence of moderate dosages of stimulant compounds, such as amphetamine, methylphenidate, nicotine, MDMA, and cocaine.
Open full explainer on EffectIndex↗Changes in felt gravity
Changes in felt gravity can be described as feeling that the pull of gravity has shifted in its direction. For example, during this state one may feel as if they are floating forwards, backwards, upwards, downwards, or in an unspecifiable direction.
Open full explainer on EffectIndex↗Dehydration
Dehydration can be described as an uncomfortably dry mouth and feelings of general thirstiness that results due to a lack of water intake. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds such as, stimulants, psychedelics, opioids, dissociatives, deliriants, cannabinoids, alcohol, and antipsychotics.
Open full explainer on EffectIndex↗Difficulty urinating
Difficulty urinating (also known as urinary retention) can be described as the experience of a decreased ability to pass urine. It is most commonly induced under the influence of heavy dosages of stimulant and opioid compounds, such as heroin, fentanyl, kratom, amphetamine, MDMA, and 4-FA.
Open full explainer on EffectIndex↗Dizziness
Dizziness can be described as the perception of a spinning or swaying motion which typically causes a difficulty in standing or walking. It is most commonly induced under the influence of heavy dosages of GABAergic depressant compounds, such as benzodiazepines, alcohol, and GHB.
Open full explainer on EffectIndex↗Increased blood pressure
Increased blood pressure can be described as a condition in which the pressure in the systemic arteries is elevated to abnormal levels. It is most commonly induced under the influence of heavy dosages of deliriants and vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.
Open full explainer on EffectIndex↗Increased heart rate
Increased heart rate or tachycardia is described as a heart rate that is faster than the normal heart rate at rest. It is most commonly induced under the influence of heavy dosages of stimulating compounds, such as traditional stimulants, certain psychedelics, and certain dissociatives.
Open full explainer on EffectIndex↗Increased perspiration
Increased perspiration, or hyperhidrosis, can be described as a condition characterized by increased sweat which is in excess of that required for the regulation of body temperature. It is most commonly induced under the influence of stimulants, psychedelics, and benzodiapine or alcohol withdrawals.
Open full explainer on EffectIndex↗Optical sliding
Optical sliding can be described as a physical effect which inhibits the coordination and control of a person's eyes by suppressing their ability to keep them still. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Pain relief
Pain relief can be described as an effect which suppresses negative sensations such as aches and pains. It is most commonly induced under the influence of moderate dosages of a very wide variety of compounds, such as opioids, GABAergics, GABApentinoids, cannabinoids, dissociatives, muscle relaxants, and NSAID's.
Open full explainer on EffectIndex↗Physical autonomy
Physical autonomy can be described as the experience of a person's own body performing simple or complex actions entirely of its own accord. It is most commonly induced under the influence of heavy dosages of dissociative compounds, such as ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Physical disconnection
Physical disconnection is the experience of feeling distant and detached from one's sense of touch and their feelings of ownership and control over their own physical body. This effect is most commonly induced under the influence of moderate dosages of depressant and dissociative compounds, such as, ketamine, PCP, and DXM.
Open full explainer on EffectIndex↗Sedation
Sedation can be described as a decrease in a person's physical energy levels which are interpreted as discouraging when it comes to wakefulness, movement, performing tasks, talkativeness, and general exercise. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as opioids, GABAergics, and antipsychotics.
Open full explainer on EffectIndex↗Seizure
An epileptic seizure (colloquially a fit) can be described as a brief episode of signs and/or symptoms which are due to abnormal, excessive, or synchronous neuronal activity in the brain. They are most commonly induced under the influence of withdrawals from prolonged chronic benzodiazepine or alcohol usage.
Open full explainer on EffectIndex↗Spatial disorientation
Spatial disorientation is the failure to perceive or perceiving incorrectly the position, motion, or altitude of oneself within the fixed coordinate system provided by the surface of the Earth and the gravitational vertical. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as diphenidine, ketamine, and DXM.
Open full explainer on EffectIndex↗Stimulation
Stimulation can be described as an increase in a person's physical energy levels. It is most commonly induced under the influence of stimulant compounds, such as amphetamine, MDMA, and cocaine.
Open full explainer on EffectIndex↗Other
1Perspective distortion
PsychonautWiki lists Perspective distortion as a reported subjective effect for 3-HO-PCE. A concise EffectIndex summary is not available for this entry.
View on PsychonautWiki↗No effects match that search.
Timing
Only onset and total duration are available for this route, so an intensity curve would be misleading.
Detailed phase timing is not available from this source.
After effects2 hours
Testing
Reagent test reference
The colour bars follow the written reaction sequence from the source. Rows without a bar are explicit results recorded by the source, not missing data. Reagents cannot establish identity, purity, or potency.
Reported appearance: Brown.
Reported appearance: Brown.
Reported appearance: Dark brown.
Reported appearance: Black.
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